Precision Longevity
Physician-Guided NAD+
Nationwide NAD+ biomarker testing · Physician interpretation · Clinically studied oral NAD+ formulation
Nationwide NAD+ biomarker testing · Physician interpretation · Clinically studied oral NAD+ formulation
The Physician’s Perspective
“There are hundreds of NAD+ products. Which one should I trust?”
Patients repeatedly asked Dr. Han the same question:
The challenge wasn’t finding a product. It was knowing which scientific evidence deserved to be trusted.
NAD+ biology has become an important area of scientific research. However, commercial NAD products vary substantially in formulation and supporting evidence. Research supporting NAD biology—or even a particular ingredient—does not necessarily mean that a specific finished product has been evaluated in a randomized human trial. Many products are also used without objective biomarker assessment or structured physician follow-up, making it difficult to understand an individual’s biological response.
Most patients don’t have the time to read clinical trials or evaluate study quality. That’s where physician judgment becomes valuable.
Rather than recommending products simply because they became popular, Dr. Han waited until stronger human evidence became available. The publication of a randomized, double-blind, placebo-controlled trial evaluating an orally administered intact NAD+ formulation provided sufficient scientific evidence to justify taking a fresh look at the field.
Hairthetics Precision Longevity™ was designed to bring together physician evaluation, peer-reviewed evidence, specialized testing when appropriate, and individualized follow-up within a single clinical program.
Hairthetics Precision Longevity™ is a physician-guided NAD+ testing and oral NAD+ program led by Shiwei Han, MD, PhD. Specialized NAD+ biomarker testing is coordinated nationwide through a partnered CLIA-certified laboratory. Testing starts at $199, and physician-guided programs start at $2,999. The specific oral NAD+ formulation used in the program was evaluated in a randomized, double-blind, placebo-controlled human trial. Review the human evidence or read the NAD+ frequently asked questions. The short trial demonstrated an intracellular NAD+ biomarker increase; it did not establish longer life, disease prevention, or long-term clinical benefits.
Many longevity products are purchased as consumer supplements with little objective assessment or structured follow-up. Hairthetics approaches longevity differently—as an ongoing physician-led clinical process rather than a one-time purchase.
Good longevity care isn’t just about choosing a product. It is about understanding whether an intervention is appropriate, measuring the response when appropriate, and adjusting over time.
When clinically appropriate, Hairthetics incorporates specialized NAD biomarker testing as part of an individualized medical evaluation.
Use a physician-directed oral NAD+ repletion protocol when appropriate.
When appropriate, repeat objective testing to better understand your individual biological response.
Refine the maintenance strategy based on your response, goals, and clinical context.
Measure
When clinically appropriate, Hairthetics incorporates specialized NAD biomarker testing as part of an individualized medical evaluation.
Replete
Use a physician-directed oral NAD+ repletion protocol when appropriate.
Reassess
When appropriate, repeat objective testing to better understand your individual biological response.
Personalize
Refine the maintenance strategy based on your response, goals, and clinical context.
NAD+ is a molecule present in every cell. It helps cells produce energy, repair DNA, respond to stress, regulate inflammation, and support many of the processes that keep cells functioning normally.
NAD levels tend to decline with age, which is one reason researchers are examining how NAD biology relates to:
Scientific interest in NAD biology is not, by itself, proof of a clinical outcome. The goal of Hairthetics Precision Longevity™ is not simply to raise NAD, but to understand your biology and determine whether targeted NAD repletion is appropriate
Unlike precursor-based approaches such as NR or NMN, the oral formulation used in Hairthetics Precision Longevity™ provides NAD+ itself through a proprietary oral delivery system.
The formulation was designed to preserve intact NAD+ while modifying its physical organization and behavior in solution to support oral delivery.
53%
INCREASE IN WHOLE-BLOOD INTRACELLULAR NAD AT DAY 6 VERSUS PLACEBO
The oral NAD+ formulation used in the program was evaluated in a randomized, double-blind, placebo-controlled human trial in adults ages 45–75.
Rather than asking whether NAD biology is important, the study addressed a specific question: whether orally administered intact NAD+ could increase intracellular NAD+ in humans.
After five days of oral supplementation with this specific NAD+ formulation, intracellular NAD+ measured in whole blood was 53% higher than placebo at Day 6. The study also showed signs that the increased NAD+ was being actively utilized by the body—not simply increasing in the blood. This matters because NAD+ supports fundamental cellular functions including energy production, metabolic regulation, DNA repair, and cellular stress response. Treatment was reported as well tolerated during the short study period.
Why formulation-specific evidence matters: Read Not All NAD+ Products Are the Same to understand how evidence for this finished oral formulation differs from generic NAD+ claims, precursor research and other delivery systems.
Research reference: Kornilov SA, et al. GeroScience. Published July 30, 2026. Read the full peer-reviewed article · DOI: 10.1007/s11357-026-02399-1
Hairthetics believes important longevity decisions should be guided by objective information whenever appropriate. Specialized NAD biomarker testing can provide an additional layer of information before treatment and during follow-up, helping us understand each patient’s individual biological response over time.
| 01 | Consult | Dr. Han reviews your medical history, goals, current therapies, and clinical context. |
| 02 | Test | When appropriate, specialized NAD biomarker testing helps establish an objective baseline before treatment recommendations are made. |
| 03 | Replete | Begin a medically supervised oral NAD+ repletion protocol when appropriate. |
| 04 | Retest | Measure again to evaluate your individual biological response. |
| 05 | Optimize | Build an individualized maintenance strategy around your response, results, and goals. |
Testing and protocols may vary based on clinical circumstances. Not every patient requires the same testing or intervention.
An important technology within a personalized clinical program—not a product in place of one.
Hairthetics Precision Longevity™ incorporates a clinically studied oral NAD+ formulation as one component of a personalized physician-led longevity program.
90 DAYS · $2,999
A focused introduction to NAD+ repletion.
6 MONTHS · $3,599
Extended repletion followed by maintenance
12 MONTHS · $4,999
Our most comprehensive long-term NAD+ program.
01
One NAD+ measurement at the time that matters to you.
02
Measure before beginning and again after treatment.
03
Three measurements across your program: baseline, approximately six months, and a final measurement, providing additional information to guide ongoing maintenance and optimization.
Program duration and specialized NAD biomarker testing are selected with Dr. Han based on clinical appropriateness, individual goals, and response to care.
A structured, medically guided approach instead of self-prescribing supplements.
A data-driven approach to cellular health that fits a demanding lifestyle.
Objective testing and physician guidance for those already exploring NAD support.
For people who value objective biological measurement alongside how they feel.
Shiwei Han, MD, PhD, is a surgeon-scientist whose medical career combines clinical medicine with biomedical research.
His background in biomedical research shapes how every emerging therapy is evaluated: through scientific reasoning, critical appraisal of the evidence, and careful translation of research into patient care.
At Hairthetics, every emerging technology is evaluated through the same framework:
Only then is it considered for incorporation into patient care. The goal is not to recommend every new longevity technology.
The goal is to recommend the right technologies at the right time, supported by the best available evidence.
Good medicine doesn’t begin with a product.
It begins with a question. Evidence-based medicine evolves, and responsible recommendations evolve with it.
That is a strength—not inconsistency.
Hairthetics Precision Longevity™ reflects our current interpretation of the best available human evidence, applied thoughtfully and individually to each patient.
“What does the evidence support today?”
Medically reviewed by Shiwei Han, MD, PhD · Last reviewed: August 2026
NAD+ is a molecule present in every cell. It helps cells produce energy, repair DNA, respond to stress, regulate inflammation, and support many of the processes that keep cells functioning normally.
Researchers are studying NAD biology in relation to healthy aging, cardiovascular health, cognitive health, immune function, and metabolic health. These are active areas of research—not proof that NAD+ supplementation prevents disease or produces a specific clinical benefit.
NAD levels tend to decline with age as the body’s production, recycling, cellular demand, and breakdown of NAD change over time. The degree of decline can vary by tissue and individual.
The program uses an orally administered intact NAD+ formulation developed with a proprietary oral delivery technology. It provides NAD+ itself rather than an NAD precursor.
NR and NMN are precursor molecules the body can use to make NAD+. The oral formulation used by Hairthetics contains intact NAD+ itself. These are different scientific approaches, and the distinction does not imply that precursor approaches are ineffective.
No. The formulation used in this program is administered orally. IV NAD+ is administered intravenously in a clinical setting and follows a different delivery route.
Yes. The specific oral NAD+ formulation used in Hairthetics Precision Longevity™ was evaluated in a randomized, double-blind, placebo-controlled human trial in adults ages 45–75.
After five days of supplementation with this specific formulation, intracellular NAD+ measured in whole blood was 53% higher than placebo at Day 6. The study also showed signs that the increased NAD+ was being utilized by the body. This short trial did not establish long-term clinical benefits or disease prevention.
Whether oral NAD+ “works” depends on what outcome is being measured and on the specific formulation. In a randomized, double-blind, placebo-controlled human trial, the specific oral NAD+ formulation used by Hairthetics increased intracellular NAD+ measured in whole blood by 53% versus placebo at Day 6. The study demonstrated a biological effect, but it was not designed to establish long-term clinical benefits or disease prevention.
Scientific evidence supporting NAD biology or an individual ingredient does not necessarily establish that every finished NAD+ product produces the same biological response. The specific oral formulation used by Hairthetics was itself evaluated in a randomized, double-blind, placebo-controlled human trial. The reported 53% increase therefore applies to the formulation that was actually studied and should not be generalized to every NAD+ product. No head-to-head trial has compared this formulation directly with other marketed products.
Specialized NAD biomarker testing provides an objective measurement that may help establish a baseline or assess biological response over time. It is an additional source of information—not a diagnosis—and must be interpreted within the patient’s broader clinical context.
Yes. Specialized laboratory testing can measure NAD biomarkers in blood, although this testing is not routinely available through many conventional laboratories. Hairthetics can coordinate specialized NAD biomarker testing when clinically appropriate and interpret the result within the patient's broader clinical context.
Hairthetics can coordinate specialized NAD biomarker testing nationwide through a partnered CLIA-certified laboratory. A testing kit is mailed directly to the patient, the required blood sample can be collected by a local phlebotomist, and the completed kit is returned to the laboratory for analysis. Results are typically available within 7–14 business days and are interpreted by Dr. Han within the context of the patient’s overall longevity strategy.
Physician-reported protocols often use a short repletion phase followed by individualized maintenance. Dosing and duration are determined by the treating physician.
Testing is not required for every patient. When clinically appropriate, Hairthetics can arrange specialized NAD biomarker testing anywhere in the United States through a partnered CLIA-certified laboratory. The kit is mailed directly to you, your blood sample can be collected by a local phlebotomist, and the completed kit is mailed back to the laboratory for analysis. Results are typically available within 7–14 business days and are interpreted by Dr. Han as part of your overall longevity strategy.
This is a complicated question, and current human evidence cannot yet answer it. In cell and animal studies, restoring NAD+ has improved several aging-related measures, including metabolic and mitochondrial function, vascular function, inflammatory signaling, muscle performance, and resilience to stress. Human trials of other NAD+ approaches have not established longer lifespan or consistent long-term clinical benefits. The specific oral NAD+ formulation used by Hairthetics has demonstrated an increase in intracellular NAD+ in a short-term human trial, but it has not yet been evaluated for long-term clinical endpoints. Therefore, long-term population studies would be needed to determine whether increasing NAD+ influences human lifespan.
Hairthetics provides the oral NAD+ formulation within a medically supervised program that begins with an appropriate clinical evaluation.
No. Medical history, medications, conditions, and individual goals should be reviewed before starting.
